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7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine

Triazolo-pyramidine derivative

CAS: 1202402-40-1

Molecular Formula: C20H21N7O3

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  5. 7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine

7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine - Names and Identifiers

Name Triazolo-pyramidine derivative
Synonyms CPI444
CS-2828
CPD1110
CPI 444
CPI-444
Ciforadenant
Triazolo-pyramidine derivative
(S)-7-(5-Methyl-furan-2-yl)-3-[6-(tetrahydro-furan-3-yloxyMethyl)-pyridin-2-ylMethyl]-3H-[1,2,3]triazolo[4,5-d]pyriMidin-5-ylaMine
(S)-7-(5-Methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine
7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
CAS 1202402-40-1

7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine - Physico-chemical Properties

Molecular FormulaC20H21N7O3
Molar Mass407.43
Density1.55±0.1 g/cm3(Predicted)
Melting Point169-171°C
Boling Point676.9±65.0 °C(Predicted)
Solubility DMSO:≥ 125 mg/mL
Appearancesolid
ColorBeige
pKa4.05±0.30(Predicted)
Storage Condition-20°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine - Preparation solution concentration reference

 1mg5mg10mg
1 mM2.454 ml12.272 ml24.544 ml
5 mM0.491 ml2.454 ml4.909 ml
10 mM0.245 ml1.227 ml2.454 ml
5 mM0.049 ml0.245 ml0.491 ml
Last Update：2024-01-02 23:10:35

7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine - Reference Information

application CPI-444 is an effective selective A2A receptor (A2AR) inhibitor to induce anti-tumor response.
use CPI-444 is an oral antagonist of A2A receptor, which binds to adenosine receptor on the surface of immune cells.
biological activity Ciforadenant(CPI-444, V81444) is an effective selective Adenosine A2A receptor antagonist, which binds to A2AR with a Ki value of 3.54 nM, and its selectivity to A2AR is more than 50 times higher than that of other adenosine receptor subtypes.
target TargetValue A2AR () 3.54 nM(Ki)
TargetValue
A2AR () 3.54 nM(Ki)
Last Update：2024-04-09 21:54:55
7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Triazolo-pyramidine derivative Visit Supplier Webpage Request for quotation
CAS: 1202402-40-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Triazolo-pyramidine derivative Visit Supplier Webpage Request for quotation
CAS: 1202402-40-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine
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